Side effects of malaria pills
Antimalarial medication is a must when travelling to a country where malaria is widespread. This includes over 200 destinations.
Using these pills is the most efficient way to prevent infection alongside insect repellent and bite prevention. Like all medicines, they can cause side effects; however, not everybody experiences them.
In case you’re travelling abroad and concerned about it, read on to find out more about side effects and which type of medication might be best for you
malaria tablets
When it comes to choosing malaria tablets, you have a few different options depending on how much time you have before you set off. The following types are available from our online clinic.
Doxycycline
It is a cost-effective antimalarial tablet that offers 90-100% protection when taken correctly. This contains the active ingredient doxycycline hyclate, which works by halting the growth of the malaria parasite and thereby killing it. It comes in the form of a daily tablet that is started two days before travel and continues for another four weeks after you return.
Malarone
It is one of the most popular types of antimalarials. This is a branded malaria tablet that contains two active ingredients, atovaquone and proguanil hydrochloride. It works by killing the malaria parasite. To be effective, you must take one tablet at the same time each day, starting two days before visiting a malaria risk area and for seven days after you leave.
Atovaquone with proguanil
It is the unbranded form of Malarone. It’s a more cost-effective option with the same active ingredients that work to kill the malaria parasite.
Mefloquine (Lariam)
Mefloquine, sometimes known by the brand name Lariam, is another antimalarial tablet that can be taken when you’re travelling to areas where there’s a risk of malaria. Usually, adults take one 250mg of mefloquine a week to prevent malaria. It’s normally recommended you start taking this between two and three weeks ahead of you travel, and keep taking them for four weeks after your return.
Mefloquine isn’t advised if you:
- Are you pregnant, breastfeeding or trying for a baby
- Have epilepsy
- Have a heart condition
- Have had severe anxiety, have had depression or some other mental health conditions
- Have had Blackwater fever
- Have hypersensitivity
- Have had an allergic reaction to quinine
Side effects of Doxycycline
It is uncommon for Doxycycline to cause side effects. On occasion, some people may experience:
- Nausea
- Diarrhoea
- Headaches
- Sore throat
- Vaginal yeast infections
. Side effects of Malarone
The most common side-effects of Malarone are usually mild, but more serious side-effects can occur occasionally. Please have a look at the patient leaflet. Most commonly reported side effects are:
- Headache
- Abdominal pain
- Nausea
- Vomiting
- Diarriahoe
Side effects of atovaquone with proguanil
Atovaquone with proguanil is the generic version of Malarone, and so the side effects are the same. They’re usually mild, but more serious side effects can occur occasionally. Please have a look at the patient leaflet. Most commonly reported side effects are:
- Headache
- Abdominal pain
- Nausea
- Vomiting
- Diarrhoea
Learn more about atovaquone with proguanil to gain further information.
Mefloquine side effects
The most commonly reported side effects of this medicine are nausea, vomiting, diarrhoea, dizziness, difficulty in sleeping and bad dreams; they are usually mild and may not cause people to stop taking the medicine; however, consultation from a service provider is needed.
Some people might experience side effects when taking mefloquine, the most common ones include:
- Feeling nauseous or being sick
- Tummy ache
- Diarrhoea
- Headaches
- Dizzy spells, losing balance
- Problems with vision
- Itchy skin
- Problems sleeping
- Nightmares
- Feeling panicky, restlessness or anxiety
- Depression
- Confusion
If you experience any of the mental health side effects, you should try and get a different antimalarial as soon as possible. Speak to a clinician and they’ll be able to advise you on what might be the best alternative.
Unusual side effects of malaria tablets
As with any medication, other side effects can occur. Rare side effects occur in fewer than one in 1000 people.
Doxycycline can cause rare side effects, including:
- Anxiety
- Difficulty swallowing
- Flushing of the skin
- Tinnitus
- Loss of appetite
- Diarrhoea
- Abdominal pain
- Severe headache and blurred vision
- Jaundice
- Inflammation of the liver
- Loosening of the nail from the nail bed
Atovaquone with Proguanil and Malarone can cause vivid dreams or hallucinations. Other side effects have also been reported; however, their exact frequency is unknown. This includes peeling skin, blisters, mouth ulcers, indigestion, nightmares, panic attacks, seizures, inflammation of blood vessels, an increase in heart rate, liver inflammation and blockage of the bile ducts.
Severe reactions to malaria tablets
Allergic reactions or serious side effects are rare, but they occasionally happen. If you experience any of the following side effects after taking malaria tablets, then you must see a doctor and stop taking the medication.
Allergic reactions
Allergic reactions can happen when taking any drug. Signs to look out for include:
- Sudden wheezing
- Difficulty in breathing
- Swelling to the face, lips, tongue or eyelids
- Chest pain
If any of the above occur, you should seek emergency medical help by calling 999 or going to A&E.
Skin reactions
Allergies can also appear on the skin, causing a rash or itching. This may present as a widespread rash with blisters and peeling skin, or one that may look like small targets with central dark spots.
Contact a doctor immediately if you experience a skin reaction after taking malaria tablets.
What is the best anti-malaria tablet?
Different malaria tablets are better suited to different people depending on their age, weight and health. If you are pregnant or planning to conceive, you need to discuss your travel plans with your GP or travel clinic. This is because most antimalarials are not ideal in pregnancy, and a full risk vs benefit assessment is needed.
Children under 12 years old can also not take Doxycycline.
In summary, there are a number of different types of malaria tablets that can help to protect against the disease. Each of which is available through dedicated travel clinics, in some pharmacies and some GP surgeries or online with the LloydsPharmacy Online Doctor service. Like all medication, malaria tablets to cause side effects; however, sometimes people can experience symptoms such as nausea, diarrhoea and headaches. If you experience any severe side effects such as abdominal pain or an allergic reaction, you should seek urgent medical attention.
